To solve the problem of temperature and humidity measurement in factory, this paper designs a wireless monitoring system based on ZigBee technology. It solves the question of highcost, established network more complex, small network coverage compare with the traditional wired system. This paper programmed operation interface of PC platform using LabVIEW language, adopting CC2530 to establish wireless sensor networks, and utilizing TSYS01 temperature sensor and HTU21D humidity sensor as a node to set up the whole temperature and humidity monitoring system. This paper also introduces the fundamental principle of this system, the circuit design and software solution of coordinator, as well as the terminal node. In order to get higher accuracy, the monitoring system obtains temperature and humidity data from sensors, then uses linear fitting to do error compensation between standard data and sensorsreceived data. The experimental result shows that only the temperature measurement error of this system is less than 0.1℃, and humidity measurement error is less than 2%RH, it can measure the temperature and humidity precisely.