In this paper, the monitoring system of tire pressure monitoring system (tire pressure monitoring system) was developed, which was based on the working principle and characteristics of tire pressure monitoring system. This paper introduced the working principle and characteristics of the mainstream tire pressure monitoring system, and expounded the design principle of the test platform from two aspects of hardware design and software design. The hardware system included the system pressure control module, temperature control module, the central control console module, the bus simulation monitoring module and the host computer module. And the software system is consisted of the bus simulation interface, the test center control interface and the bus signal monitoring interface. In this paper, the test for accuracy of the test bench and the real test with tire pressure monitoring system were performed to verify the working performance of the test bench. The accuracy test result indicated that the accuracy of the test bench was in accordance with the requirements and the tire pressure monitoring system real test showed good convenience and accuracy.