Gel electrophoresis analysis technique is mainly used for qualitative and quantitative analysis of nucleic acid and protein genetic material. In recent years, with the progress of science and technology, more and more technical requirements for gel electrophoresis analysis have become one of the important issues. The gel electrophoresis image analysis system based on the computer digital image technology can solve the disadvantages of the traditional method, which has convenient operation and high precision. High quality images are the primary condition for the analysis and calculation of useful information. In the process of generation and transmission, the gel electrophoresis image may be polluted by noise or blurred by image. Wavelet transform based image denoising and image enhancement can be very good to remove the image noise, and the image of the useful information to enhance. After experimental comparison, there is a significant effect.