As the testing parameter of the home environment is single and the control for home comfort cannot be achieved, a measurement and control system for wireless smart home comfort level is designed based on STM32F103RBT6 microprocessor. STM32 MCU collects the environmental parameters such as indoor temperature, air humidity, light intensity, concentration of harmful gases and dust concentration, and controls the start and stop of home electrical appliances according to the standard comfort, to control home comfort level. At the same time, the parameters are uploaded to the mobile terminal via WiFi module and GSM module, and Android software of mobile terminal is applied for remote monitoring of home comfort situation. Through field testing, the system can realize accurate and realtime measurement and control of home comfort, which shows the feasibility and stability of the system.