Establishment of reasonable regional active vibration control model is studied in this paper, and it focuses on the mapping function of regional vibration responses to observing parts in vibration control, and optimizes the sensor/actuator configuration. Active vibration control in no individual body often uses the finite dimensional controller to control the infinite dimensional distributed parameter systems, but it leads to many problems in practical engineering. MATLAB simulation is applied in this article, based on the onedimensional simple cantilever beam, it selects certain nodes by equidistance, to identify the external load. According to the sensor responses of selected points , vibration response for all positions are orthogonal polynomial fitting, and the polynomial coefficients are solved in the dynamic model of active vibration control; with the optimal objective function determined by the vibration response and the application of particle swarm optimization algorithm, the research on the optimal locations of control actuators under the same sensor locations in testing position and the different characteristics of external excitation is surveyed.