Voice is the main bridge for people to communicate with each other.Voice communication processing in the real world will be subject to a variety of interference, from the interference of voice as much as possible to remove noise and improve voice quality, is the field of modern signal processing is one of the most important technology.The LMS adaptive filtering method is introduced, and a variable step size LMS is proposed, and the adaptive noise cancellation of wavelet threshold noise reduction and LMS combining is realized.The simulation results show that the wavelet threshold combined with the noise of LMS is the best, and the signal - to - noise ratio is improved greatly, and the speech quality is improved by using the sound of different male and female voice.