A multi channel high speed data acquisition system is designed in this paper, to monitor the SingleEvent Effects in the DC/DC converter SEE test. Based on the PXIe bus, the system adopts Programmable instrument network structure. Its highest data transmitting speed may reach 400 MB/s. The SingleEvent Effects tests for the Domestic DC/DC was carried out at the accelerator of the Institute of Modern Physics, Chinese Academy of Sciences, and SingleEvent Effects detection is carried out by using the measurement and control system.Experimental results show that the system can effectively detect single event effects of DC/DC power supply. In the future, this system can be widely used in the assessment of domestic DC/DC power supply for aerospace applications.