Aiming at the insufficient utilization of transient power frequency current components when single-phase grounding fault occurs in high voltage grounding system. To this end, a fault line selection for grounding fault based on improved SSA-VMD and MFE is proposed. First, the EOBL is used to improve the population diversity of the SSA, with the improved SSA to optimize VMD parameters, which can be obtained from the experimental data, the optimized variational modal decomposition can accurately distinguish the power frequency components of the transient zero-sequence current of each feeder. Secondly, the multi-scale fuzzy entropy value of the power frequency component of the zero-sequence current of each feeder is calculated, and PMMFE is used as line selection criterion then the mistake line is selected. MATLAB/Similink results show that this method can select the right line under most mistake conditions, with high reliability and strong robustness.