In order to meet the quantitative evaluation needs of the comprehensive destructive power of the shock wave, heat and seismic wave damage elements in the explosive energy release process of different reaction mechanisms and different drug-containing energetic material states, experimental data on shock wave overpressure, impulse, heat dose, and seismic wave vibration velocity at different distances from the blast center were used. On the basis of the laws of change of shock wave overpressure, impulse, heat dose, and seismic wave vibration velocity with blast center distance and proportion distance, a comprehensive evaluation model that can comprehensively evaluate the "strength" of different blast center distances and different power parameters was established by using the normalized weighting method. The validity of the established comprehensive evaluation model was verified by using standard TNT test data, and the relative error of the computed equivalent energy was less than 2%. At the same time, the comprehensive evaluation model also realized the calculation of the comprehensive equivalent energy of the shock wave, heat, and seismic wave energy release characteristics of a certain type of energetic material under the same test conditions. The multi-power parameter comprehensive evaluation method can select arbitrary weights based on different test environments, test scenarios, and damage targets, and obtain the equivalent energy of the target damage capability of the test material under specific conditions, which can provide effective quantitative analysis methods for the design, development, and analysis of explosive energy release characteristics, as well as the comprehensive evaluation of damage capability.