In order to study the strain response characteristics of reinforced concrete targets under continuous impact, this paper conducted two finite element simulations of the infiltration and explosion warhead, and carried out simulation experiments of continuous impact of the infiltration and explosion warhead on reinforced concrete targets. The overall experimental process was divided into penetration implosion penetration implosion. By comparing the simulation data with the experimental data, the effectiveness of the simulation model was verified, and the law of strain response was summarized. The results showed that the relative errors between the simulated and experimental strain peaks during the first strike were 4.2%, 8.5%, and 13.8%, respectively. The second simulation had a large simulation error due to the cumulative effect of the target, but it still reflected the nature of the strain. After continuous strikes, cracks appear on the back of the target and gradually expand, and the duration of strain response in the experimental data increases.