Abstract: In view of the large amount of computation and high real-time requirement in the process of video image processing, this paper designs a DSP+FPGA high-definition image real-time processing system based on SDI interface, which mainly includes hardware circuit design and software programming debugging. The main processor of the system adopts Xilinx series of Spartan-6 FPGA and TMS320C6748 DSP of TI Company. Data receiving and transmitting units adopt two new chips, GV7704 and GV7700, which are newly listed by SEMTECH Company. The system software part includes data acquisition and logic control on the FPGA, data reception and processing on the DSP, and data communication between the two through the UPP and EMIF interfaces. The experimental results show that the system can realize the acquisition of the video image of the SDI camera, and output the image data through the VGA interface circuit, with high definition.