The B/S smart home control system based on HTML 5 is proposed to solve the problem that a wide variety of smart home’s system and equipments, numerous of communication protocol, and user control interface is incompatible with each other and hard to configure. This paper designs a multi-protocol conversion gateway which integrated four wired/wireless subsystems include ZigBee, Bluetooth, Wi-Fi, and wired Ethernet, the gateway put data into the MySQL database, database middleware defines the equipment event table, state/control trigger table, the home page construct with HTML5, realized free add/delete equipment, equipment manual controlling in the web page, customer could control logic by drag and drop event element. Experimental results show that the control system based on HTML5 is easy to use, control effectively, and is able to control the smart home system of the multi-protocol gateway.